Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and thymol (THY) alone and in combination with antifungal agents (fluconazole, itraconazole, ketoconazole, clotrimazole, miconazole, terbinafine and nystatin) against M. pachydermatis. The assays were performed according to the Clinical and Laboratory Standards Institute (CLSI), using Sabouraud dextrose broth and checkerboard microdilution. The mean fractional inhibitory concentration index (FICI) showed primary synergies for the combinations carvacrol+nystatin, thymol+nystatin, and carvacrol+miconazole (80%). In conclusion, the results obtained indicate that the phytochemicals tested showed relevant in vitro anti-M. pachydermatis activity. Future in vivo experiments are needed to elucidate the safety and therapeutic potential of these combinations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mycmed.2019.08.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Canine Malassezia dermatitis (CMD) and otitis externa are generally treated by antifungal drugs. However, azole-resistant strains have been isolated from canine skin and ear canals worldwide. Phytochemicals isolated from essential oils are effective alternatives for inhibiting Malassezia pachydermatis.
View Article and Find Full Text PDFEffect of Java plum () leave extract and a silver nanoparticles synthesis on pathogens in skin diseases of dogs.
Open Vet J
October 2024
Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Background: Antibiotic use has been rising in both humans and animals. The growing concern over antimicrobial drug resistance and the promotion of regional drug use have led to a rise in the interest in medicinal applications of herbs combined with biosynthesized nanoparticles.
Aim: To evaluate the antimicrobial and acaricidal effects of leaves crude extract (Sc-CE) and biosynthesized silver nanoparticles (Sc-AgNPs) on dog skin pathogens and determined the optimal concentration and time for application.
Fungal dysbiosis following antibacterial monotherapy in canine otitis externa.
J Small Anim Pract
November 2024
Department of Clinical Sciences and Services, University of London, Hatfield, UK.
Article Synopsis
- The study aimed to investigate whether treating refractory bacterial otitis in dogs with specific topical antibiotics leads to an increase in yeast overgrowth, particularly Malassezia.
- Twenty-nine dogs were treated with either fluoroquinolone or a combination of piperacillin and tazobactam, and ear swabs were taken to measure bacterial and yeast levels before and after treatment.
- Results showed a significant reduction in bacterial infections after treatment, but a notable increase in yeast (especially in dogs treated with piperacillin/tazobactam), highlighting the importance of monitoring for yeast overgrowth during antibacterial treatment.
Synergistic effect of essential oils and chlorhexidine against planktonic and biofilm-forming cells of .
Vet Anim Sci
December 2024
Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Košice, Komenského, 73, 041 81, Košice, Slovakia.
() , is often associated with secondary infection of the skin and external auditory canal in dogs and cats. The treatment of infections is based on the local application of antifungals often combined with antiseptics. Due to increased resistance of yeast to commonly used antimycotics, especially in biofilm-forming cells, the use of natural substances, e.
View Article and Find Full Text PDFMinimum inhibitory and bactericidal/fungicidal concentration of commercially available products containing essential oils, zinc gluconate, or 4% chlorhexidine for Malassezia pachydermatis, Pseudomonas aeruginosa, and multi-drug resistant Staphylococcus pseudintermedius canine clinical isolates.
Vet Res Commun
December 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Ave, Gainesville, FL, 32610, USA.
Article Synopsis
- Skin infections are prevalent in humans and animals, and the rise of multi-drug resistant (MDR) infections prompts a search for alternatives to traditional antimicrobials, like essential oils.
- The study assessed the effectiveness of various commercial products with essential oils, zinc gluconate, and chlorhexidine against MDR strains of bacteria and fungi using microbroth dilution techniques.
- Results showed that essential oils and zinc gluconate products demonstrated significant antibacterial and antifungal potency, suggesting they may serve as viable treatments for skin infections in companion animals, though further studies are required to validate these findings.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!