The corpus callosum is the largest bundle of commissural fibres that transfer information between the two cerebral hemispheres. Callosal projection neurons (CPNs) are a diverse population of pyramidal neurons within the neocortex that mainly interconnect homotopic regions of the opposite cortices. Nevertheless, some CPNs are involved in heterotopic projections between distinct cortical areas or to subcortical regions such as the striatum. In this study, we showed that the axon guidance receptor PlexinD1 is expressed by a large proportion of heterotopically projecting CPNs in layer 5A of the primary somatosensory (S1) and motor (M1) areas. Retrograde tracing of M1 CPNs projecting to the contralateral striatum revealed the presence of ectopic neurons aberrantly located in layers 2/3 of Plxnd1 and Sema3e mutant cortices. These results showed that Sema3E/PlexinD1 signalling controls the laminar distribution of heterotopically projecting CPNs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mcn.2019.103397 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Atypical Extraoral Presentation of a Heterotopic Gastrointestinal Cyst on the Face: A Case Report.
Cureus
July 2024
Oral and Maxillofacial Surgery, Goa Dental College and Hospital, Bambolim, IND.
Article Synopsis
- Heterotopias and choristomas are congenital lesions that consist of normal tissues found in abnormal locations, with this text focusing on a rare type known as a heterotopic gastrointestinal cyst (HGIC) found in the oral cavity.
- The case discussed involves a 42-year-old woman with a two-year history of swelling in the parotid area, which was initially misdiagnosed as more common conditions, but further investigation revealed a cystic lesion.
- Histopathological analysis showed cystic tissue with features typical of gastrointestinal lining, leading to the diagnosis of HGIC, making it the first recorded instance of such a cyst on the face, emphasizing the need for careful assessment of similar cases due to their benign but uncommon
The Effect of Therapeutic Approaches on Hallux Valgus Deformity.
Cureus
April 2024
Department of Musculoskeletal Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- Hallux valgus (HV) is a common foot condition characterized by a structural deformity of the big toe, leading to discomfort and joint movement issues, predominantly affecting females and linked to factors like age and footwear.
- This condition often appears alongside other foot issues like hammer toes and flat feet, and has an unclear cause with no known preventive treatment.
- Fibrodysplasia ossificans progressiva (FOP) is a genetic disorder that can lead to similar toe deformities and unwanted bone growth, often due to trauma; initial treatments focus on non-surgical methods, with surgery considered if these fail, generally yielding good recovery outcomes.
Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity.
Nat Commun
April 2024
CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
The corpus callosum, historically considered primarily for homotopic connections, supports many heterotopic connections, indicating complex interhemispheric connectivity. Understanding this complexity is crucial yet challenging due to diverse cell-specific wiring patterns. Here, we utilized public AAV bulk tracing and single-neuron tracing data to delineate the anatomical connection patterns of mouse brains and conducted wide-field calcium imaging to assess functional connectivity across various brain states in male mice.
View Article and Find Full Text PDFThe prevalence of elongated styloid process in the population of Barcelona: a cross-sectional study & review of literature.
BMC Oral Health
September 2023
Odontological Hospital University of Barcelona, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, L'Hospitalet de Llobregat, Spain.
Background: Styloid process (SP) is a cylindrical bony projection that originates from the inferior part of the petrous temporal bone just anteriorly to the stylomastoid foramen. Several nerves, muscles, and ligaments are related closely to the (SP). It is considered elongated when the measurement exceeds 30 mm.
View Article and Find Full Text PDFA Case Report and Literature Review of Bilateral Cervical Chondrocutaneous Branchial Remnants.
Case Rep Dermatol Med
June 2023
Department of Dermatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chondrocutaneous branchial remnants (CCBRs) are rare congenital heterotopic tissue formations originating from the first or second embryonic branchial arches. Clinically, CCBRs are characterized predominantly by unilateral and solitary cartilaginous nodules found on the lower neck region. Herein, we present a case of CCBRs in a 9-year-old male patient who presented with horn-shaped projecting masses on either side of the anterior border of the sternocleidomastoid muscle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!