The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article "Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects" (Russell et al., 2019).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700409 | PMC |
| http://dx.doi.org/10.1016/j.dib.2019.104311 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lipophilicity Modulation of Fluorescent Probes for Imaging of Cellular Microvesicle Dynamics.
J Am Chem Soc
January 2025
School of Chemistry and Chemical Engineering, Institute of Physical Science and Information Technology, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, Anhui 230601, China.
Real-time monitoring of dynamic microvesicles (MVs), vesicles associated with living cells, is of great significance in deeply understanding their origin, transport, and function. However, specific labeling MVs poses a challenge due to the lack of unique biomarkers that differentiate them from other cellular compartments. Here, we present a strategy to selectively label MVs by evaluating a series of lipid layer-sensitive cationic indolium-coumarin fluorescent probes (designated as IC-C, with ranging from 1 to 18) that feature varying aliphatic side chains (CH).
View Article and Find Full Text PDFMolecular characterization of a novel photoperiod-insensitive allele Ppd-B1a.3 and its effect on heading date in Chinese wheat (Triticum aestivum) cultivar Qingchun 37.
J Plant Res
December 2024
College of Agronomy, Northwest A & F University, Yangling, 712100, Shaanxi, China.
Breeders adjust wheat heading dates to improve regional adaptability and reduce or mitigate yield losses caused by meteorological disasters, pests and diseases. The Ppd-1 genes play a crucial role in determining wheat sensitivity to changes in day-length and serve as key regulators of heading dates once the vernalization requirement is satisfied. In this study, we identified a new allelic variant of the promoter region, Ppd-B1a.
View Article and Find Full Text PDFApatite textural and geochemical insights into the petrogenesis of intrusive rocks.
Sci Rep
December 2024
Liaoning Natural Resources Service Center, Shenyang, 110033, Liaoning, China.
Apatite is widely used as an indicator mineral to reflect the characteristics and petrogenesis of host magma. In this study, we present apatite geochemical and in-situ Sr-Nd isotopic data of monzogranite, granodiorite and dioritic enclave in the eastern Songnen-Zhangguangcai Range Massif, aiming to fingerprinting their petrogenesis and magmatic evolution processes. Based on apatite textures and geochemistry characteristics, the apatites were categorized into two distinct groups.
View Article and Find Full Text PDFHow do autistic people, professionals, and caregivers think about the origins and environments of autism.
Autism Dev Lang Impair
December 2024
Department of Philosophy, University of Antwerp, Antwerp, Belgium.
Understanding what people believe the causes of autism to be has implications for experiences of familial guilt and stigma. Using a qualitative approach, we investigated how Brazilian healthcare professionals, parents of young and adult autistic people and young and adult autistic people consider the origins of autism and the interaction between the biological and social environment concerning the challenges autistic people encounter. Eight health professionals who assist autistic people, five young autistic people, six family members of young autistic people, five autistic adults, and four parents of autistic adults participated in the research.
View Article and Find Full Text PDFBeyond the usual challenges, a case of LV summit PVCs ablation in child with ASO for D-TGA.
BMC Cardiovasc Disord
December 2024
Magdi Yacoub Heart Foundation, Cairo, Egypt.
Premature ventricular contractions (PVCs) are a common finding in patients with surgically repaired congenital heart defects including transposition of the great arteries (D-TGA). While often asymptomatic, PVCs can sometimes lead to palpitations, dyspnea, and hemodynamic compromise, requiring therapeutic intervention. The arterial switch operation is the preferred treatment for D-TGA, but these patients have a 2% incidence of ventricular arrhythmias and 1% incidence of sudden cardiac death post-operatively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!