Despite the significant progress in the recent efforts toward developing an effective vaccine against toxoplasmosis, the search for new protective vaccination strategy still remains a challenge and elusive goal because it becomes the appropriate way to prevent the disease. Various experimental approaches in the past few years showed that developing a potential vaccine against the disease can be achievable. The combination of multi-epitopes expressing different stages of the parasite life cycle has become an optimal strategy for acquiring a potent, safe, and effective vaccine. Epitope-based vaccines have gained attention as alternative vaccine candidates due to their ability of inducing protective immune responses. This mini-review highlights the current status and the prospects of vaccine development along with the application of epitope-based vaccine in the future parasite immunization as a novel under development and evaluation strategy.
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http://dx.doi.org/10.5455/javar.2019.f329 | DOI Listing |
Bioinform Biol Insights
December 2024
Discipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.
Objective: Babesiosis is a significant haemoparasitic infection caused by apicomplexan parasites of the genus . This infection has continuously threatened cattle farmers owing to its devastating effects on productivity and severe economic implications. Failure to curb the increase of the infection has been attributed to largely ineffective vaccines.
View Article and Find Full Text PDFPeerJ Comput Sci
October 2024
Department of Electrical & Electronics Engineering Faculty of Engineering and the Built Environment, University of Johannesburg, Johannesburg, South Africa.
Antigenic peptides (APs), also known as T-cell epitopes (TCEs), represent the immunogenic segment of pathogens capable of inducing an immune response, making them potential candidates for epitope-based vaccine (EBV) design. Traditional wet lab methods for identifying TCEs are expensive, challenging, and time-consuming. Alternatively, computational approaches employing machine learning (ML) techniques offer a faster and more cost-effective solution.
View Article and Find Full Text PDFPLoS One
December 2024
School of Life Science and Technology, Institut Teknologi Bandung, Bandung, West Java, Indonesia.
J Biomol Struct Dyn
November 2024
Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India.
The global dengue outbreak is a significant public health concern, with the World Health Organization recording over 3 million cases and a 0.04% case fatality rate until July 2023. The infection rate is anticipated to rise in vulnerable regions worldwide.
View Article and Find Full Text PDFJ Nanobiotechnology
November 2024
College of Basic Medicine, Army Medical University, Gaotanyan str. 30, Chongqing, 400038, China.
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