The role of mRNA mA methylation in the nervous system.

Cell Biosci

School of Public Health, China Medical University, Shenyang, 110122 Liaoning China.

Published: August 2019

Epitranscriptomics, also known as "RNA epigenetics", is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (mA) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The mA modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA mA methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA mA methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701067PMC
http://dx.doi.org/10.1186/s13578-019-0330-yDOI Listing

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