Background: The population of patients designated as alternate level of care (ALC) consists predominantly of frail older adults who are medically stable and awaiting discharge from hospital. They have complex medication regimens, often including potentially inappropriate medications (PIMs). There has been increasing emphasis on managing the burden that ALC patients place on the health care system, but little is known about their health care needs.
Objective: To characterize the medication regimens, including use of PIMs, of ALC patients at the study institution.
Methods: A cross-sectional chart audit of ALC patients was conducted between May and July 2017. For all patients in the sample, each medication was categorized by therapeutic class, and PIMs were categorized according to the Beers criteria, the STOPP/START criteria, and an established list of high-alert medications.
Results: A total of 82 patients met the audit criteria, for whom the mean number of chronic conditions was 6.4 (standard deviation [SD] 3.3) and the mean number of prescribed medications was 12.8 (SD 6.9). Twenty-four (29%) of the patients were receiving at least 1 drug from 7 different drug classes. All but one of the patients had PIMs in their regimen; the frequency of PIMs was highest according to the Beers criteria (mean 3.9 [SD 2.6] medications per patient).
Conclusions: At the study institution, ALC patients had on average more than 6 chronic conditions managed with at least 12 medications, of which one-quarter were PIMs. These data will be used to inform next steps in making recommendations to simplify, reduce, or discontinue medications for which there is an unclear indication, lack of effectiveness, or evidence of potential harm.
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Neurooncol Adv
November 2024
Huntsman Cancer Institute, Salt Lake City, UT, USA.
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Hematology Department, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
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December 2024
Department of Anesthesiology and Perioperative Medicine, Penn State Medical Center, Hershey, PA, United States.
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Braz J Infect Dis
December 2024
Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina, Divisão de Enfermidades Infecciosas, São Paulo, SP, Brasil; Antimicrobial Resistance Institute of São Paulo (ARIES), São Paulo, SP, Brasil.
Candidemia is the predominant form of invasive candidiasis and the most frequently occurring serious fungal infection in critically ill patients in Intensive Care Units (ICU). Studies carried out in Latin America reveal a higher incidence of candidemia and higher mortality rates when compared to North America or Europe. This highlights the need to develop guidelines for correctly diagnosing and treating candidemia in critically ill patients in the ICU.
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December 2024
Center of Bone Biology, Institute for Anatomy, Faculty of Medicine, Dr Subotica starijeg 4, 11000 Belgrade, Serbia. Electronic address:
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