The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC value of 5.4 µM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41429-019-0223-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
sp. nov., a novel cellulose-degrading actinobacterium isolated from soil and emended description of the genus .
Int J Syst Evol Microbiol
October 2022
Key Laboratory of Agricultural Microbiology of Heilongjiang Province, Northeast Agricultural University,, No. 59 Mucai Street, Xiangfang District, Harbin 150030, PR China.
A novel cellulose-degrading actinobacterium, designated strain NEAU-S10, was isolated from soil collected from Chifeng, Inner Mongolia Autonomous Region, PR China, and characterized using a polyphasic approach. Pairwise similarity of the 16S rRNA gene sequence showed that strain NEAU-S10 was a representative of and was closely related to NEAU-yn17 (99.2 %), SA152 (99.
View Article and Find Full Text PDFSaccharothrix algeriensis NRRL B-24137, the first non-Streptomyces actinobacterium, produces holomycin after cystine feeding.
Arch Microbiol
November 2020
Laboratoire de Biologie des Systèmes Microbiens (LBSM), Ecole Normale Supérieure de Kouba, Alger, Algeria.
Saccharothrix algeriensis NRRL B-24137 is an actinobacterium isolated from Algerian Saharan soil. This strain has the ability to produce several dithiolopyrrolone antibiotic derivatives depending on the precursors added to the culture medium. This group of antibiotics is known for their potent antimicrobial and anticancer activities.
View Article and Find Full Text PDFBiobleaching of mechanical paper pulp using Streptomyces rutgersensis UTMC 2445 isolated from a lignocellulose-rich soil.
J Appl Microbiol
January 2020
Wood and Forest Products Division, Research Institute of Forest and Rangelands, Agricultural Research Education and Extension Organization (AREEO), Tehran, Iran.
Aims: The utilization of micro-organisms in pulp and paper industries has proved biobleaching technology as an environmentally friendly alternative to the conventional approach. In this paper, the effect of actinobacterial fermentation broth on pulp biobleaching has been investigated.
Methods And Results: Actinobacterial colonies were isolated from lignocellulose-rich soil samples and screened for xylanase production and bleaching activity.
Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis.
J Antibiot (Tokyo)
January 2020
Microbial Strain Collection, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124, Braunschweig, Germany.
The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.
View Article and Find Full Text PDFA new dithiolopyrrolone antibiotic triggered by a long fermentation of Saccharothrix algeriensis NRRL B-24137 in sorbic acid-amended medium.
Lett Appl Microbiol
October 2019
Laboratoire de Biologie des Systèmes Microbiens, Ecole Normale Supérieure de Kouba, Alger, Algeria.
Saccharothrix algeriensis NRRL B-24137 is an actinobacterium isolated from Algerian Saharan soil. It produces bioactive compounds belonging to the dithiolopyrrolone class of antibiotics, which are characterized by the possession of a unique pyrrolinonodithiole nucleus. Dithiolopyrrolones are known for their strong antibacterial and antifungal activities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!