Daily Dosing for Bedaquiline in Patients with Tuberculosis.

Antimicrob Agents Chemother

Bill and Melinda Gates Foundation, Seattle, Washington, USA

Published: November 2019

The bedaquiline regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB) in adults is a loading dose of 400 mg QD for 2 weeks followed by 200 mg thrice weekly (TIW) for 22 weeks. Most TB antibiotics administered with bedaquiline are given QD. Using pharmacokinetic simulations, we explored alternative QD bedaquiline regimens and determined that 200 mg QD for 8 weeks followed by 100 mg QD provides comparable exposures to the approved regimen. This simpler regimen is under clinical evaluation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811417PMC
http://dx.doi.org/10.1128/AAC.00463-19DOI Listing

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