AI Article Synopsis
- Decreased bone mass is a significant issue for patients with inflammatory bowel diseases (IBD), leading to a higher risk of osteoporotic fractures, yet it is often overlooked in their treatment.
- Researchers are exploring how variations in the estrogen receptor gene impact bone mineral density (BMD) in patients with ulcerative colitis (UC) and Crohn's disease (CD), which may contribute to both osteoporosis and inflammation.
- In a study of 197 IBD patients, they found that women with CD had notably lower bone density, specifically linked to certain genetic markers, revealing a potential predictive relationship between gene variations and osteoporosis risks in this group.
Article Abstract
Decreased bone mass in patients with inflammatory bowel diseases (IBD) is a clinical problem with extremely severe consequences of osteoporotic fractures. Despite its increasing prevalence and the need for mandatory intervention and monitoring, it is often ignored in IBD patients' care. Determining the biomarkers of susceptibility to bone mineral density disorder in IBD patients appears to be indispensable. We aim to investigate the impact of estrogen receptor gene () gene polymorphisms on bone mineral density (BMD) in patients with ulcerative colitis (UC) and Crohn's disease (CD), as they may contribute both, to osteoporosis and inflammatory processes. We characterised 197 patients with IBD (97 with UC, 100 with CD), and 41 controls carrying out vitamin D, calcium and phosphorus serum levels, and bone mineral density assessment at the lumbar spine and the femoral neck by dual-energy X-ray absorptiometry (DXA), genotyping and haplotype analysis. We observed that women with CD showed the lowest bone density parameters, which corresponded to the c.454-397T and c.454-351A allele dose. The gene PvuII and XbaI TA (px) haplotype correlated with decreased femoral neck T-score (OR = 2.75, CI = [1.21-6.27], -value = 0.016) and may be predictive of osteoporosis in female patients with CD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780775 | PMC |
| http://dx.doi.org/10.3390/jcm8091306 | DOI Listing |
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