AI Article Synopsis

  • Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma, typically presenting with skin patches, plaques, tumors, or widespread redness, and can eventually affect lymph nodes and blood.
  • The diagnosis is challenging, especially in the early "pre-mycotic" stage when it may look like eczema or psoriasis; persistent lesions and lack of treatment response are warning signs.
  • A case study of a 72-year-old man showed a two-year history of a unique skin eruption resembling tiger-like stripes, which was diagnosed through a histopathologic exam and treated successfully with NB-UVB phototherapy.

Article Abstract

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. Mycosis fungoides classically presents in the skin as patches, plaques, tumors, or erythroderma, progressing to involve the lymph nodes and peripheral blood. The many clinical variants, with different histologic patterns, and the subtle early clinical and histologic changes may delay early diagnosis and present a diagnostic challenge for clinicians. The greatest challenge in diagnosis is the pre-mycotic stage, which may closely resemble eczematous or psoriasiform dermatitis clinically and histologically. The persistence of lesions and inadequate response to treatment are the first warning signs. Later stages of MF have a poor prognosis with poor therapeutic response and fatal outcome. We describe a 72-year-old man, who presented with a two-year history of an unusual eruption, which started on the abdomen, around the waistline, and gradually spread to involve his back, trunk, and buttocks. Clinically, the skin eruption presented as tiger-like stripes. The diagnosis was confirmed after histopathologic examination. The patient was treated with NB-UVB phototherapy with marked improvement.

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