Platelet count and mean platelet volume predict atypical pre-eclampsia.

Objective: We aimed to analyze the role of platelet count (PC), mean platelet volume (MPV), and ratio of PC to MPV (PC/MPV) in predicting and/or diagnosing atypical pre-eclampsia (PE).

Study Design: We performed a retrospective case-control analysis of these platelet parameters in healthy pregnant women with normal blood pressure (control) and the changes that occurred in patients with atypical PE and PE.

Main Outcome Measures: We performed statistical analysis to evaluate the prognostic and predictive significance of PC, MPV, and PC/MPV and the combined effects of these parameters in the parturient population (N = 300) composed of 100 controls, 100 atypical PE cases, and 100 PE cases.

Results: The PC, MPV, and PC/MPV in both atypical PE and PE were significantly different to that in the controls. After adjusting for confounding factors using the ordinal logistics regression model, we found that PC/MPV, N% and BMI were independent risk factors for PE and atypical PE(The odds ratio was 0.925, 1.028 and 1.071). The model's C-index is 0.684.

Conclusion: We found that the PC, MPV, and PC/MPV may be changed in atypical PE patients who did not have significant PE symptoms. Our results indicated that it could be a diagnostic method to predict atypical PE during pregnancy. PC/MPV and the other platelet parameters can play a role in predicting the development of atypical PE, leading to better diagnosis and management of atypical PE.