Accelerated longitudinal designs (ALDs) are designs in which participants from different cohorts provide repeated measures covering a fraction of the time range of the study. ALDs allow researchers to study developmental processes spanning long periods within a relatively shorter time framework. The common trajectory is studied by aggregating the information provided by the different cohorts. Latent change score (LCS) models provide a powerful analytical framework to analyze data from ALDs. With developmental data, LCS models can be specified using measurement occasion as the time metric. This provides a number of benefits, but has an important limitation: It makes it not possible to characterize the longitudinal changes as a function of a developmental process such as age or biological maturation. To overcome this limitation, we propose an extension of an occasion-based LCS model that includes age differences at the first measurement occasion. We conducted a Monte Carlo study and compared the results of including different transformations of the age variable. Our results indicate that some of the proposed transformations resulted in accurate expectations for the studied process across all the ages in the study, and excellent model fit. We discuss these results and provide the code for our analysis.
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http://dx.doi.org/10.1080/00273171.2019.1647822 | DOI Listing |
Neurogastroenterol Motil
January 2025
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Background: The carbon-13 spirulina gastric emptying breath test (GEBT) is approved to identify delayed, but not accelerated, gastric emptying (GE). We compared the utility of the GEBT to scintigraphy for diagnosing abnormal GE in patients with diabetes mellitus.
Methods: Twenty-eight patients with diabetes ate a 230-kcal test meal labeled with technetium 99 m and C-spirulina, after which 10 scintigraphic images and breath samples (baseline, 15, 30, 45, 60, 90, 120, 150, 180, 210, and 240 min) were collected on 2 occasions 1 week apart.
Clin Pharmacokinet
January 2025
Facultés de Médecine et de Pharmacie de Lyon, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Background And Objective: Limited information is available on the pharmacokinetics of rifampicin (RIF) along with that of its active metabolite, 25-deacetylrifampicin (25-dRIF). This study aimed to analyse the pharmacokinetic data of RIF and 25-dRIF collected in adult patients treated for tuberculosis.
Methods: In adult patients receiving 10 mg/kg of RIF as part of a standard regimen for drug-susceptible pulmonary tuberculosis enrolled in the Opti-4TB study, plasma RIF and 25-dRIF concentrations were measured at various occasions.
Introduction: Niacin is a non-statin lipid-lowering therapy that has been shown to lower triglycerides and improve other risk factors for renal outcomes. Despite these favorable data, the effect of niacin on long-term kidney outcomes remains unclear. The aim of this study is to examine the associations of niacin therapies with incident chronic kidney disease (CKD), end-stage renal disease (ESRD), and death in patients with estimated glomerular filtration (eGFR) of at least 60 mL/min/1.
View Article and Find Full Text PDFJ Ren Nutr
January 2025
Department of Nursing and Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, C/ Santiago Ramón y Cajal s/n 46115, Alfara del Patriarca, Valencia, Spain.
Objective: The aim was to assess the intra and inter-rater reliability of the handheld dynamometry testing of lower limb muscles during hemodialysis.
Methods: This is a cross-sectional study including subjects undertaking hemodialysis for at least 3 months. Handheld dynamometer measurements of hip and ankle muscle strength (N) were registered on 4 different occasions, 2 trials by raters A and 2 by raters B, to evaluate the intra and inter-rater reliability.
Disabil Rehabil
January 2025
Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
Purpose: The Trunk Impairment Scale-modified Norwegian version (TIS-modNV) measures trunk control for clinical and research purposes. This study examined the validity and reliability of the TIS-modNV in people with multiple sclerosis (pwMS).
Materials And Methods: Sixty-eight pwMS (mild to moderate) participated.
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