Dependence on Dectin-1 Varies With Multiple Species.

Four spp. (, , , ) cause >95% of invasive infections. elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to and , however, whether Dectin-1 is important for host defense against or is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse spp. We found that Dectin-1 mediates innate cytokine responses to these spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent while they mostly survived infection with less virulent spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple spp., although the specific roles for Dectin-1 varies with different spp.