Vitamin D and calcium are essential nutrients for bone health, to achieve peak bone mass and to preserve bone as age advances. A deficiency in these nutrients casts a long shadow in later life in the form of short/long latency diseases-rickets/osteomalacia/osteoporosis. There is scant review available about the trend of these nutrients in India. For over past half a century, the intake of dietary calcium, milk, milk products, and cereals has declined drastically in the background of upward revision of RDA/RDI in modern India. This is attributed to changing lifestyle, inadequate milk consumption across various socio-economic strata, and shift in dietary intake from cereals to rice and wheat. There is a clear rural-urban divide in consumption of milk, milk products and cereals, a change in dietary habits which magnify the calcium and vitamin D deficiency. Revisiting of RDA guidelines for calcium along with public health measures is required to tackle the morbidity arising due to the deficiency in these nutrients. Any measure to addresses this issue in isolation, without achieving the desired benefits, is a disservice to the population. Population based educational strategies, government measures, leveraging technology, adequate sun exposure and food fortification help in tackling the twin nutrient deficiencies in this diverse country.
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http://dx.doi.org/10.3389/fendo.2019.00493 | DOI Listing |
Phytomedicine
January 2025
Centre for Industrial Biotechnology Research, Siksha 'O' Anusandhan Deemed to be University, Campus 2, Kalinganagar, Bhubaneswar-751003, Odisha, India. Electronic address:
Background: Medicinal plants have historically been the cornerstone of treatment for a myriad of ailments. With modern pharmacology, many contemporary drugs have been derived from traditional medicine practices. Essential oils from these plants, known for their anti-inflammatory capabilities, have played a significant role in treating conditions such as cardiovascular and inflammatory skin diseases, as well as joint inflammation.
View Article and Find Full Text PDFComput Biol Chem
January 2025
Department of Biostatistics and Bioinformatics, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India. Electronic address:
Plastics play an essential role in modern fisheries and their degradation releases micro- and nano-sized plastic particles which further causes ecological and human health hazards through various environmental contamination pathways and toxicity mechanisms, which can cause respiratory problems, cancer, reproductive toxicity, endocrine disruption and neurological effects in humans. This study utilized various bioinformatics tools through multi-step computational analyses to investigate the interactions between prevalent fisheries microplastics and the key protein receptor acetylcholinesterase (AChE), which is associated with neurotoxicity, as it can interfere with nerve impulses and muscle control. Our results indicate that the binding of seven polymers within AChE's active site, with dodecane and polypropylene exhibited highest affinity with hydrogen bonding were observed through Molecular docking of different program (PyRx) and servers (CB-Dock, eDock) then the stability of AChE-dodecane and AChE-polypropylene complexes were observed through MD simulations for 100 ns.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.
Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, including their transition from liquid to solid forms, while addressing the formulation strategies, characterization techniques, and future prospects in pharmaceutical sciences. The review systematically analyzes existing studies on SEDDS, focusing on their classification into liquid and solid forms and their preparation methods, including spray drying, hot-melt extrusion, and adsorption onto carriers.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Department of Civil Engineering, National Institute of Technology, Warangal 506004, Telangana State, India.
Modern innovations increasingly prioritize eco-friendliness, aiming to pave the way for a sustainable future. The field of civil engineering is no exception to this approach, and, in fact, it is associated with almost every sustainable development goal framed by the United Nations. Therefore, the sector has a pivotal role in achieving these goals.
View Article and Find Full Text PDFMicromachines (Basel)
January 2025
Department of Mechanical Engineering, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia.
In modern ICs, sub-threshold voltage management plays a significant role due to its perspective on energy efficiency and speed performance. Level shifters (LSs) play a critical role in signal exchange among multiple voltage domains by ensuring signal integrity and the reliable operation of ICs. In this article, a Pass-Transistor-Enabled Split Input Voltage Level Shifter (PVLS) is designed for area, delay, and power-efficient applications with a wide voltage conversion range.
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