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The pressure-derived microvascular resistance reserve and its correlation to Doppler MRR measurement-a proof of concept study.
Front Cardiovasc Med
June 2024
Kálmán Laki Doctoral School of Biomedical and Clinical Sciences, University of Debrecen, Debrecen, Hungary.
Background: Microvascular resistance reserve (MRR) is a recently introduced specific index of coronary microcirculation. MRR calculation can utilize parameters deriving from coronary flow reserve (CFR) assessment, provided that intracoronary pressure data are also available. The previously proposed pressure-bounded CFR (CFRpb) defines the possible CFR interval on the basis of resting and hyperemic pressure gradients in the epicardial vessel, however, its correlation to the Doppler wire measurement was reported to be rather poor without the correction for hydrostatic pressure.
View Article and Find Full Text PDFComparing Pressure-Bounded Versus Thermodilution-Derived Coronary Flow Reserve in Unobstructed Coronary Arteries.
Am J Cardiol
July 2024
Royal Papworth Hospital, Cambridge, United Kingdom; University of Cambridge, Cambridge, United Kingdom. Electronic address:
Diagnostic performance of pressure-bounded coronary flow reserve.
Cardiovasc Interv Ther
April 2024
Department of Cardiology, Tokyo Medical University Hachioji Medical Center, 1163 Tate-machi, Hachioji, Tokyo, 193-0998, Japan.
Article Synopsis
- Fluid dynamics research suggests coronary flow reserve (CFR) can be derived from coronary artery pressure measurements, leading to the exploration of pressure-bounded coronary flow reserve (pb-CFR) against traditional CFR assessments in patients.
- A study involving 62 patients used a pressure guidewire to gather data on both pb-CFR and conventional CFR, revealing a moderate correlation between the two (r = 0.54) but significant discrepancies in agreement.
- The findings indicate that while pb-CFR shows potential for identifying patients without significant epicardial coronary artery disease, it may not reliably substitute for traditional CFR methods in certain cases, especially with patients having diffuse disease or high fractional flow reserve (FFR).
Prognostic value of combined fractional flow reserve and pressure-bounded coronary flow reserve: outcomes in FFR and Pb-CFR assessment.
Minerva Cardiol Angiol
April 2024
Sacred Heart Catholic University, Rome, Italy.
Background: Coronary flow reserve (CFR) has an emerging role to predict outcome in patients with and without flow-limiting stenoses. However, the role of its surrogate pressure bounded-CFR (Pb-CFR) is controversial. We investigated the usefulness of combined use of fractional flow reserve (FFR) and Pb-CFR to predict outcomes.
View Article and Find Full Text PDFValidation of pressure-bounded coronary flow reserve using invasive coronary physiologic assessment.
Heart Vessels
May 2023
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8677, Japan.
Coronary flow reserve (CFR) represents entire coronary compensatory capacity. While CFR assessment is recommended to identify patients at an increased risk of cardiovascular events and coronary microvascular dysfunction, invasive CFR measurement is often technically challenging. Although not well validated yet, pressure-bounded CFR (pbCFR) has been proposed as a simple surrogate to estimate impaired CFR.
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