To evaluate the effect of surgery on olfactory function in patients with chronic rhinosinusitis with nasal polyps（CRSwNP） by subjective and objective olfactory tests. This was a retrospective study. Forty patients with CRSwNP who underwent endoscopic sinus surgery（ESS） from 2015 to 2017 in Beijing Anzhen Hospital were enrolled. Postoperative time was 6-46 months. The patients were followed up in October 2018 and examined using Sniffin' sticks olfactory test and olfactory event-related potentials （oERP）. The polyps collected during surgery were performed to eosinophil count and percentage calculation. They were divided into eosinophilic CRSwNP（ECRS） and non-eosinophilic CRSwNP（NECRS）. The subjective and objective olfactory functions between the two groups were compared before and after surgery respectively and the paired T test was performed between the postoperative and the preoperative Sniffin' sticks olfactory test. Covariance analysis was used to adjust the effect of different postoperative time on postoperative olfactory recovery. There were 21（52.5%） ECRS and 19（47.5%） NECRS patients of the 40 patients with nasal polyps. There was statistical difference in the posterior ethmoid score and the posterior olfactory cleft score of CT. According to the criterion of total TDI increased more than 5.5, olfactory function in 21（52.5%） patients had improved. In addition, there was a significant improvement in olfactory function in ECRS group either in unilateral T/TDI or bilateral T/D/TDI, but only unilateral T/TDI increased in NECRS group. There was no significant difference in Sniffin' sticks olfactory test between the two groups, but there was a statistically significant difference in the latency of oERP after surgery. ESS could improve olfactory function in patients with CRSwNP by more than 50%. Bilateral olfactory improvement in ECRS was better than that in NECRS, but olfactory function in postoperative ECRS was still lower than that in NECRS. oERP can more objectively and accurately reflect the severity of olfactory disorders associated with eosinophilic inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.13201/j.issn.1001-1781.2019.08.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insight into the Relationships Between Chemical, Protein and Functional Variables in the PBP/GOBP Family in Moths Based on Machine Learning.
Int J Mol Sci
March 2025
Laboratorio de Química Ecológica, Departamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingenieria y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile.
During their lives, insects must cope with a plethora of chemicals, of which a few will have an impact at the behavioral level. To detect these chemicals, insects use several protein families located in their main olfactory organs, the antennae. Inside the antennae, odorant-binding proteins (OBPs), as the most studied protein family, bind volatile chemicals to transport them.
View Article and Find Full Text PDFNeglected Microbes in Floral Nectar: Influence of Filamentous Fungi on Nectar Scent and Parasitoid Olfactory Responses.
J Chem Ecol
March 2025
Department of Agricultural, Food and Forest Sciences, University of Palermo, Palermo, 90128, Italy.
Floral nectar is a sugar-rich resource which is ubiquitously inhabited by a wide array of microorganisms. Fermentation by nectar-inhabiting microbes can alter several nectar traits, including nectar scent, via changes in the blend of volatile organic compounds (VOCs). Although there is growing evidence on how yeasts and bacteria influence the foraging behavior of flower-visiting insects, the potential role of other microbial taxa that can colonize nectar has been largely neglected.
View Article and Find Full Text PDFFan therapy for breathlessness - how do you do it and why?
Curr Opin Support Palliat Care
March 2025
Wolfson Palliative Care Research Centre, University of Hull, Hull, East Yorkshire, UK.
Purpose Of The Review: This review summarises high-level evidence for fan therapy and adds a commentary on the relatively-neglected question of how to optimise benefits based on qualitative evidence, clinical experience and broader research and theory.
Recent Findings: Recent high-level evidence suggests the fan reduces time to recovery from episodic breathlessness rather than reduces daily levels over a longer period. Lower grade evidence suggests the fan can also help people increase their physical activity.
Olfactory Effects of Chemotherapy Combined with Bevacizumab on Advanced-Stage Colorectal Cancer Patients: Chemotherapy and Olfaction.
Indian J Otolaryngol Head Neck Surg
February 2025
Otolaryngology Department, Gazi University, Ankara, Türkiye.
Impaired olfaction negatively impacts nutrition and appetite, particularly gaining more significance in cancer patients for whom nutrition and calorie intake are crucial. In our study, we aimed to investigate the effects of advanced-stage colorectal cancer treatment on olfactory functions. Fourteen patients (78.
View Article and Find Full Text PDFWhole-brain mapping in adult zebrafish and identification of the functional brain network underlying the novel tank test.
eNeuro
March 2025
Department of Biological Sciences, Wayne State University, Detroit, MI 48202.
Zebrafish have gained prominence as a model organism in neuroscience over the past several decades, generating key insight into the development and functioning of the vertebrate brain. However, techniques for whole brain mapping in adult stage zebrafish are lacking. Here, we describe a pipeline built using open-source tools for whole-brain activity mapping in adult zebrafish.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!