AI Article Synopsis
- The study focuses on synthesizing new compounds called 1,4-dihydropyridines (DHPs) that combine features of melatonin and nimodipine to address multiple targets.
- One of the compounds, DHP 7, showed significant calcium channel blocking ability at 55% and strong antioxidant properties equivalent to 8.78 Trolox equivalents.
- DHP 7 is highlighted as a promising candidate for potential Alzheimer's disease therapy due to its balanced profile of effects.
Article Abstract
In this work we describe the synthesis, Ca channel blockade capacity and antioxidant power of N,N-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced DHP analyzed here, for potential Alzheimer's disease therapy.
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| http://dx.doi.org/10.1016/j.bioorg.2019.103205 | DOI Listing |
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