Rate of bactericidal activity for Branhamella catarrhalis of fleroxacin compared with that of amoxycillin-clavulanic acid.

The rate of bactericidal activity of fleroxacin was compared with that of the combination of amoxycillin and clavulanic acid (in the proportion of 4 to 1) on beta-lactamase producing strains of Branhamella catarrhalis. The rate of bactericidal activity of 1 mg/l was as rapid as that of 1 mg/l of amoxycillin-clavulanic acid combination. This rate was not significantly more rapid if the concentrations of fleroxacin were increased to 10 mg/l. In conclusion, the bactericidal activity of fleroxacin is at least as good as that of the combination of amoxycillin and clavulanic acid. Fleroxacin showed a bactericidal effect for B. catarrhalis at concentrations that would be achieved in humans.