Investigation of the marine-derived fungus led to the isolation of a new enantiomer of tricinonoic acid, namely (-)-tricinonoic acid (), and a new polyketide spartinol E (), together with three known compounds ().
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Enhanced Synthesis, Purification, and Characterization of a Marine Bacterial Consortium-Derived Protease Enzyme With Destaining and Keratinolytic Activity.
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School of Bioengineering, Zunyi Medical University, Zhuhai, China.
Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs.
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Increasing evidence underscores the pivotal role of tumor angiogenesis for tumorigenesis and tumor metastasis. Inhibiting the tumor angiogenesis process is a promising therapeutic approach for cancer. In order to search for natural angiogenic inhibitors, the chemical constitutes of a marine-derived fungus Eutypella sp.
View Article and Find Full Text PDFOverexpression of the Global Transcriptional Regulator LaeA Leads to Production of Cyclic Lipopeptides in Marine-Derived Aspergillus niger L14.
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School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
Overexpression of a global transcriptional regulator LaeA was performed to awaken cryptic biosynthetic gene clusters (BGCs) in a marine sponge-derived fungus, Aspergillus niger L14, to obtain secondary metabolites (SMs), and resulted in the production of five previously undiscovered SMs in the wild-type strain, including three cyclic lipopeptides aspochracin (1), JBIR-15 (2) sclerotiotide C (3), kojic acid (4) and penicillic acid (5). Bioassays revealed that compound 2 displayed promising antimicrobial effects on Candida albicans with a minimum inhibitory concentration value of 32 µg/mL and 4 exhibited significant antioxidant activity with a similar half-maximal inhibitory concentration value (5 µg/mL) to that of ascorbic acid. Transcriptome analysis results indicated that the overexpression of LaeA in strain L14 remarkably enhanced the expression of genes involved in polyketide synthase-non-ribosomal peptide synthetase hybrids and amino acid metabolism, demonstrating an effective approach for the production of cyclic lipopeptides.
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