AI Article Synopsis
- TSLP, a cytokine associated with allergic reactions, may work with CD40L to increase IL-23 production in psoriasis, a skin condition caused by an inappropriate immune response.
- The study involved 53 psoriasis patients, classified by severity based on the PASI score, and compared their serum TSLP levels to a control group of 53 healthy individuals.
- Results indicated significantly higher TSLP levels in psoriasis patients compared to controls, with levels correlating positively with disease severity, suggesting TSLP could be a potential marker for psoriasis severity.
Article Abstract
Background: The proallergic cytokine, thymic stromal lymphopoietin (TSLP) may synergize with T cell-derived CD40 ligand (CD40L) to allow IL-23 production in patients with psoriasis. IL-23 is a central cytokine that mediates the inappropriate immune reaction in patients with psoriasis.
Objective: The aim of the study was to correlate serum level of TSLP with psoriasis severity.
Methods: The study was carried out on 53 patients with psoriasis. They were divided into mild, moderate, and severe according to PASI score. The patients' ages ranged from 10 to 62 years. The patients included 29 males and 24 females. A total of 53 healthy subjects with matched age and sex served as control group. Blood samples were collected from the venous blood of the patients and control subjects then the serum was separated. The serum samples were immediately frozen at -20°C. Serum TSLP was measured by Sandwich Enzyme-linked Immunosorbant Assay (ELISA).
Results: There was a statistically very highly significant increase (<0.001) in serum TSLP levels among the case group (1042.7±812.93) compared to the control group (314.21±220.78). There was also a statistically very highly significant increase (<0.001) in serum TSLP levels with increased psoriasis severity estimated by PASI score.
Conclusion: In this study, we found that serum TSLP is elevated in psoriasis patients and is correlated with disease severity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679690 | PMC |
| http://dx.doi.org/10.2147/PTT.S212774 | DOI Listing |
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