AI Article Synopsis
- Researchers created a detailed transcriptional atlas that maps the gene activity of malaria parasites throughout their entire life cycle across various hosts and environments.
- The atlas includes data from thousands of individual parasites and defines specific developmental stages for three different species of human malaria parasites.
- The Malaria Cell Atlas serves as both a comprehensive overview of gene function in these parasites and a freely available resource for further research into malaria.
Article Abstract
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056351 | PMC |
| http://dx.doi.org/10.1126/science.aaw2619 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!