AI Article Synopsis
- Early menopause is linked to better airflow performance in lungs but doesn’t affect lung capacity or risk of lung restriction according to a Mendelian randomisation study of 94,742 women.
- The study found that women with early menopause (<45 years) had higher forced expiratory volume (FEV) ratios and a 15% lower risk of airflow obstruction compared to those with normal menopause ages (45-55 years).
- Observational analyses showed that early menopause was associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, highlighting a gap between observational studies and MR findings that needs further investigation.
Article Abstract
In observational studies, early menopause is associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, but not airflow obstruction. It is, however, unclear if this association is causal. We therefore used a Mendelian randomisation (MR) approach, which is not affected by classical confounding, to assess the effect of age at natural menopause on lung function.We included 94 742 naturally post-menopausal women from the UK Biobank and performed MR analyses on the effect of age at menopause on forced expiratory volume in 1 s (FEV), FVC, FEV/FVC, spirometric restriction (FVC
Download full-text PDF
Source
http://dx.doi.org/10.1183/13993003.02421-2018 DOI Listing Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!