: Study the association of adropin and hypertensive disorders complicating pregnancy (HDCP). : Patients with HDCP were matched with normotensive women (47 pairs). Adropin concentrations were detected by enzyme-linked immunosorbent assay. : Compared with the controls, the serum adropin levels were lower in the HDCP group ( < 0.001) and in HDCP subgroups (gestational hypertension, mild preeclampisa, and severe preeclampsia, term, preterm, early onset, and late onset) (all < 0.05). After adjustment for confounders, adropin remained negatively associated with HDCP ( = 0.027). : Lower adropin concentration is significantly associated with HDCP, suggesting that higher or normal adropin levels may be protective against HDCP.
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