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New Peptides from The Marine-Derived Fungi and . | LitMetric

New Peptides from The Marine-Derived Fungi and .

Mar Drugs

Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.

Published: August 2019

Four new peptides were isolated from the culture broths of the marine-derived fungi and ochraceopetaliformis. Based on the results of chemical and spectroscopic analyses, two compounds ( and ) from were determined to be cyclopentapeptides, while those from ochraceopetaliformis were a structurally-related cyclodepsihexapeptide () and its linear analog (). In addition to the presence of a D-amino acid residue, the almost reversed sequence of peptides in and , relative to those of the and , is notable. These new compounds exhibited moderate inhibition against the enzyme sortase A as well as a weak inhibition against isocitrate lyase ().

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780696PMC
http://dx.doi.org/10.3390/md17090488DOI Listing

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