BK channels, originally discovered in as (), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BK channels in cellular and organ protection possibly for their ability to modulate mitochondrial function. However, the direct role of BK channels in regulating mitochondrial structure and function is not deciphered. Here, we demonstrate that BK channels are present in fly mitochondria, and mutants show structural and functional defects in mitochondria. mutants display an increase in reactive oxygen species and the modulation of ROS affected their survival. We also found that the absence of BK channels reduced the lifespan of , and overexpression of human BK channels in flies extends life span in males. Our study establishes the presence of BK channels in mitochondria of and ascertains its novel physiological role in regulating mitochondrial structural and functional integrity, and lifespan.
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| http://dx.doi.org/10.3390/cells8090945 | DOI Listing |
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