Making therapy decisions in oncology is a challenging task in the medical precision era. Oncotherapy is a decision support system that provides oncologists with suitable therapies for the patient within the national guidelines. The system is capable, on the one hand, to help the oncologist to maximize fitting therapy to the patient and, on the other hand, to provide control tools for the country's sanitary authorities.
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Case report: Tracing in parallel the salivary and gut microbiota profiles to assist Larotrectinib anticancer treatment for fusion-positive glioblastoma.
Front Oncol
November 2024
Department of Pharmacy, University of Naples "Federico II", Naples, Italy.
Oncotherapy can shape intestinal microbiota, which, in turn, may influence therapy effectiveness. Furthermore, microbiome signatures during treatments can be leveraged for the development of personalised therapeutic protocols in cancer treatment based on the identification of microbiota profiles as prognostic tools. Here, for the first time, the trajectory of gut and salivary microbiota in a patient treated with Larotrectinib, a targeted therapy approved for diagnosed glioblastoma multiforme neurotrophic tyrosine receptor kinase () gene fusion-positive, has been accurately investigated.
View Article and Find Full Text PDFRevising cancer incidence in a Central European country: a Hungarian nationwide study between 2011-2019 based on a health insurance fund database.
Front Oncol
October 2024
Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary.
Background: The nationwide HUN-CANCER EPI study examined cancer incidence and mortality rates in Hungary from 2011 to 2019.
Methods: Using data from the National Health Insurance Fund (NHIF) and Hungarian Central Statistical Office (HCSO), our retrospective study analyzed newly diagnosed malignancies between Jan 1, 2011, and Dec 31, 2019. Age-standardized incidence and mortality rates were calculated for all and for different tumor types using both the 1976 and 2013 European Standard Populations (ESP).
ChatGPT M.D.: Is there any room for generative AI in neurology?
PLoS One
October 2024
Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary.
ChatGPT, a general artificial intelligence, has been recognized as a powerful tool in scientific writing and programming but its use as a medical tool is largely overlooked. The general accessibility, rapid response time and comprehensive training database might enable ChatGPT to serve as a diagnostic augmentation tool in certain clinical settings. The diagnostic process in neurology is often challenging and complex.
View Article and Find Full Text PDFCemiplimab monotherapy in Japanese patients with recurrent or metastatic cervical cancer.
Cancer Med
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Gynaecologic Cancer Programme, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Background: In the phase 3 EMPOWER-Cervical 1/GOG-3016/ENGOT-cx9 study, cemiplimab significantly improved overall survival (OS) versus chemotherapy for patients with recurrent or metastatic cervical cancer who progressed after first-line platinum-based chemotherapy. We present a post hoc subgroup analysis of patients enrolled in Japan.
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Nanoradiopharmaceuticals: An Attractive Concept in Oncotherapy.
ChemMedChem
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Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, PR China.
Radiopharmaceuticals are of significant importance in the fields of tumor imaging and therapy. In recent decades, the increasing role of nanotechnology has led to the attractive concept of nanoradiopharmaceuticals. Consequently, it is imperative to provide a concise summary of the necessary guidelines to facilitate the translation of nanoradiopharmaceuticals.
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