Evaluation of the Fast Healthcare Interoperability Resources (FHIR) Standard for Representation of Knowledge Bases Encoded in the Arden Syntax.

Context: Arden Syntax is a standard that encodes knowledge as Medical Logic Modules (MLMs) but lacks a standard query data model and terminology.

Objective: Assess to what extent FHIR can represent MLMs.

Method: A convenience sample of 340 MLMs were examined and tabulated for representation using the PlanDefinition resource.

Result: While alignment between structured subsections is uneven, the PlanDefinition resource adequately represents procedural medical knowledge encoded as MLMs.

Conclusion: FHIR adequately represents Arden Syntax MLMs.