Social media are proposed as a complementary data source for detection and characterisation of adverse drug reactions. While signal detection algorithms were implemented for generating signals in pharmacovigilance databases, the implementation of a graphical user interface supporting the selection and display of algorithms' results is not documented in the medical literature. Although collecting information on the chronology and the impact of adverse drug reactions is desirable to enable causality and quality assessment of potential signals detected in patients' posts, no tool has been proposed yet to consider such data. We describe here two approaches, and the corresponding tools we implemented for: (1) quantitative approach based on signal detection algorithms, and (2) qualitative approach based on expert review of patient's posts. Future work will focus on implementing other statistical methods, exploring the complementarity of both approaches on a larger scale, and prioritizing the posts to manually evaluate after applying appropriate signal detection methods.
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http://dx.doi.org/10.3233/SHTI190367 | DOI Listing |
Food Chem
January 2025
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, PR China; Research Institute of Food Crops, Xinjiang Academy of Agricultural Sciences, No.403 Nanchang Road, Urumqi, Xinjiang 830091, PR China. Electronic address:
Food Chem
January 2025
Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, No.29 of 13th Street, TEDA, Tianjin 300457, PR China. Electronic address:
Identifying antioxidant phenolic compounds (APs) in food plays a crucial role in understanding their biological functions and associated health benefits. Here, a bifunctional Cu-1,3,5-benzenetricarboxylic acid (Cu-BTC) nanozyme was successfully prepared. Due to the excellent laccase-like behavior of Cu-BTC, it can catalyze the oxidation of various APs to produce colored quinone imines.
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January 2025
School of Food and Biological Engineering, Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Engineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei 230009, China. Electronic address:
Ultra-precision point-of-care detection of Escherichia coli O157:H7 in foods is an important issue. Here, the detection sensitivity was improved by a signal cascade amplification strategy synergised by exonuclease III assisted isothermal amplification and reverse magnetic strategy. The double-stranded DNA formed by the aptamer and the target DNA as a sensing switch, avoiding the complex process of specific nucleic acid extraction.
View Article and Find Full Text PDFFood Chem
January 2025
State Key Laboratory for Food Nutrition and Safety; College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:
In the present study, we developed a nanozyme-based direct competitive immunoassay to detect walnut allergen (Jug r 4) in foods. Walnut monoclonal antibody (mAb) and CuSe@BiMoO nanocomposites were generated to form a signal probe by electrostatic adsorption. The nanocomposites had high peroxidase-like activity and could be stored at room temperature.
View Article and Find Full Text PDFArtif Intell Med
December 2024
Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. Electronic address:
Modeling Optical Coherence Tomography (OCT) images is crucial for numerous image processing applications and aids ophthalmologists in the early detection of macular abnormalities. Sparse representation-based models, particularly dictionary learning (DL), play a pivotal role in image modeling. Traditional DL methods often transform higher-order tensors into vectors and then aggregate them into a matrix, which overlooks the inherent multi-dimensional structure of the data.
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