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Background: There are no clinical trials involving patients with diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa since antiretroviral therapy (ART) for HIV became widely available in this region. We aimed to establish the safety and efficacy of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with DLBCL in Malawi.

Methods: This prospective, single-arm, non-randomised phase 1/2 clinical trial was done at Kamuzu Central Hospital Cancer Clinic (Lilongwe, Malawi).

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Case 285: Primary Breast Lymphoma.

Radiology

January 2021

From the Departments of Radiology (M.E.K., I.T., L.L.), Pathology (A.M.), and Nuclear Medicine (A.T.), Centre Hospitalier Universitaire de Montréal (CHUM), 1051 Rue Sanguinet, Montréal, QC, Canada H2X 3H4; and Department of Radiology, McGill University Health Centre, Montréal, Quebec, Canada (B.M.).

History A 25-year-old woman was referred to our breast clinic for assessment of a palpable mass in her left breast that developed quickly in 2 weeks. She denied any associated fever, chills, redness, or pain. She had no relevant medical or surgical history; no evidence of recent pregnancy, abortion, or breastfeeding; and no family history of breast cancer.

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