AI Article Synopsis
- The study aimed to assess the properties of emulsions created by a new V-shaped emulsification device and compare their drug release characteristics to those formed using a traditional 3-way-stopcock method for chemoembolization.
- The new device achieved a high water-in-oil (W/O) percentage of 98.45% with a median droplet size of 22.58 μm and a viscosity of 143.70 cP.
- Results showed that the device released epirubicin slower than the 3-way-stopcock, with a release half-life of 175 minutes compared to just 8 minutes for the conventional method.
Article Abstract
Purpose: To evaluate physiochemical characteristics of emulsions formed by a modified emulsification device and to compare in vitro drug release properties of ethiodized oil (Lipiodol)-drug solution emulsion formed by the device and a 3-way-stopcock for conventional transarterial chemoembolization.
Materials And Methods: A V-shaped pumping emulsification device with a 100-μm-micropore glass membrane was developed to reduce the resistance of pumping. Epirubicin solution was mixed with Lipiodol (ratio 1:2) with pumping exchanges through the device. The percentage of water-in-oil (W/O) and droplet size distribution and viscosity were evaluated. The in vitro drug release properties were compared between using the device and a 3-way-stopcock.
Results: Percentage of W/O was 98.45 ± 0.03%. The median droplet size was 22.58 ± 1.70 μm, and the viscosity was 143.70 ± 12.36 cP. The released epirubicin at 0 min was 1.73 ± 1.05% in the device, whereas 41.02 ± 7.27% in a 3-way-stopcock (P < 0.001). The half-life of release (t) of the device was significantly longer than that of a 3-way-stopcock (175 ± 25 vs. 8 ± 6 min, P < 0.001).
Conclusion: The V-shaped emulsification device with a 100-μm-micropore glass membrane can form nearly 100% W/O emulsion with homogenous droplet sizes. Emulsion formed by the device showed a slower epirubicin release property compared with that of a 3-way-stopcock.
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| http://dx.doi.org/10.1007/s00270-019-02311-9 | DOI Listing |
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