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Aging platelets shift their hemostatic properties to inflammatory functions.
Blood
January 2025
University Hospital, LMU Munich, Munich, Germany.
Platelets are crucial players in hemostasis and thrombosis, but also contribute to immune regulation and host defense, using different receptors, signaling pathways and effector functions, respectively. Whether distinct subsets of platelets specialize in these diverse tasks is insufficiently understood. Here, we employed an in vivo pulse-labelling method in Mus musculus models for tracking in vivo platelet ageing and its functional implications.
View Article and Find Full Text PDFPredictive parameters of cardiovascular risk in younger school-age children.
Cent Eur J Public Health
December 2024
Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic.
Objectives: Overweight and obesity are important concerns for global health. They are characterized by excessive fat accumulation that can harm health. Childhood obesity has reached alarming levels around the world due to urbanization and changes in lifestyle.
View Article and Find Full Text PDFFactors associated with delayed referrals of patients with sepsis from primary to tertiary healthcare in Blantyre, Malawi: a qualitative study.
BMC Prim Care
January 2025
School of Global and Public Health, Kamuzu University of Health Sciences (KUHeS), Private Bag 360, Blantyre, Malawi.
Background: Sepsis is defined as invasion of pathogens into the blood stream together with the host response to this invasion. Thus, sepsis consists of the systemic inflammatory response syndrome (SIRS)caused by infection. It is a life-threatening condition that requires prompt detection and early definitive medical intervention.
View Article and Find Full Text PDFThe value of blood lactate and lactate clearance rate in evaluating the prognosis of athletes with heat illness of varying degrees after high-intensity exercise.
BMC Sports Sci Med Rehabil
January 2025
Department of Pharmacy, The 969 th Hospital of P.L.A, Hohhot, 010051, China.
Background: Heat stroke, a severe heat illness with organ damage, is a major cause of cause irreparable organ damage and higher death rates among military persons and athletes.
Objectives: To study the changes in blood lactate (Lac) levels and lactate clearance rate (LCR) in athletes with heat illness of varying degrees after high-intensity exercise and to evaluate their prognostic value.
Material And Methods: In present study, acute care unit admitted 36 heat sickness patients following high-intensity exercise from December 2019 to July 2024, with comprehensive medical records, for retrospective study.
Kidney REPLACEment therapies in patients with acute kidney injury and RHABDOmyolysis (ReplaceRhabdo): a pilot trial.
BMC Nephrol
January 2025
Medical Department III, Division of Nephrology, University Hospital Leipzig, Leipzig, Germany.
Background: Rhabdomyolysis is frequently associated with acute kidney injury (AKI). Due to the nephrotoxic properties of myoglobin, its rapid removal is relevant. If kidney replacement therapy (KRT) is necessary for AKI, a procedure with effective myoglobin elimination should be preferred.
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