Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
- Trehalose, a disaccharide that can induce autophagy, has limited medical use due to its poor absorption and effectiveness in the body.
- To enhance its pharmacological properties, researchers created trehalose-based nanolipid conjugates by linking it with squalene and betulinic acid in specific ratios.
- The study details the methods used for creating these conjugates and their nano-assemblies, along with tests that showed their ability to promote autophagy in laboratory settings.
Article Abstract
The disaccharide trehalose is an autophagy inducer, but its pharmacological application is severely limited by its poor pharmacokinetics properties. Thus, trehalose was coupled via suitable spacers with squalene (in 1:2 and 1:1 stoichiometry) and with betulinic acid (1:2 stoichiometry), in order to yield the corresponding nanolipid-trehalose conjugates , and . The conjugates were assembled to produce the corresponding nano-assemblies (NAs) , and . The synthetic and assembly protocols are described in detail. The resulting NAs were characterized in terms of loading and structure, and tested in vitro for their capability to induce autophagy. Our results are presented and thoroughly commented upon.
