AI Article Synopsis
- Researchers discovered that increasing the expression of the enzyme Setdb2 in macrophages can improve wound healing in type 2 diabetes.
- The study highlights the role of epigenetic regulation in managing inflammation and tissue repair caused by macrophages.
- These findings suggest potential new treatments for wounds in diabetic patients by targeting chromatin modifications.
Article Abstract
In this issue of Immunity, Kimball et al. (2019) show that restoring expression of the chromatin modifying enzyme Setdb2 in macrophages rescues impaired wound healing associated with type 2 diabetes. Their findings reveal epigenetic regulation as central to the resolution of macrophage-mediated inflammation in tissue repair and have therapeutic implications for the treatment of diabetic wounds.
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| http://dx.doi.org/10.1016/j.immuni.2019.07.009 | DOI Listing |
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