AI Article Synopsis
- The study aimed to understand the hypothalamic changes in individuals with Parkinson's disease (PD) by measuring hypothalamic volumes using MRI.
- Researchers analyzed MRI data from 232 people with PD and 130 healthy individuals, finding no significant difference in hypothalamic size between the two groups.
- The results indicate that while there is evidence of hypothalamic involvement in PD, it may not be detectable through volumetric measurements obtained from MRI.
Article Abstract
Background: The pathophysiology of the hypothalamic involvement in Parkinson's disease (PD) is not well understood. The objective of this study was the quantification of hypothalamic volumes in vivo in PD.
Methods: High-resolution T -weighted magnetic resonance imaging (MRI) data from 232 individuals with PD and 130 healthy non-PD individuals were used for quantification of the hypothalamic volumes.
Results: The hypothalamus in PD was not atrophied, as indicated by volumetric analyses in the prospectively collected subcohort (30 PD, V = 921 ± 78 mm vs 30 non-PD, V = 917 ± 67 mm ; P = 0.850) and validated in a large cohort (202 PD, V = 925 ± 88 mm vs 100 non-PD, V = 932 ± 114 mm ; P = 0.602).
Conclusions: Hypothalamic involvement in PD as shown by a large body of histopathological evidence does not appear to be detectable by MRI-based volumetric quantification. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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| http://dx.doi.org/10.1002/mds.27814 | DOI Listing |
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