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Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer. | LitMetric

AI Article Synopsis

  • Lung cancer is caused by uncontrolled growth of cells in the lungs, which can spread to other parts of the body through metastasis.
  • Researchers developed a new treatment using DQA-modified paclitaxel and ligustrazine micelles to target and destroy vasculogenic mimicry (VM) channels, thereby inhibiting tumor metastasis.
  • The study showed that these micelles effectively accumulated in tumor sites, demonstrated strong anti-cancer effects on A549 cells, and had minimal toxicity, suggesting a promising new strategy for treating non-small cell lung cancer (NSCLC).

Article Abstract

Lung cancer is a kind of malignant tumour characterized as uncontrolled cell growth in lung. These malignant cell growth can spread beyond the lung by process of metastasis into other tissues or parts of the body. In this study, we developed dequalinium (DQA) modified paclitaxel plus ligustrazine micelles to destroy vasculogenic mimicry (VM) channels and inhibit tumour metastasis. assays showed that the targeting micelles with centralized particle size distribution showed not only vigoroso cytotoxicity on A549 cells but also strong inhibition on VM channels and tumour metastasis. Mechanism studies indicated that the DQA modified paclitaxel plus ligustrazine micelles could down-regulate the expressions of VEGF, MMP2, TGF-β1 and E-cadherin in A549 cells. assays indicated that the targeting drug-loaded micelles could enhance the accumulation of chemotherapeutic drugs at tumour sites and exhibit strong tumour inhibitory activity with negligible toxicity. Hence, the DQA modified paclitaxel plus ligustrazine micelles developed in this study may provide a potential strategy for treatment of NSCLC.

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Source
http://dx.doi.org/10.1080/21691401.2019.1653900DOI Listing

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