The article Reprogramming of.
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http://dx.doi.org/10.1007/s00438-019-01603-6 | DOI Listing |
Stem Cell Res Ther
December 2024
Experimental Cardiology Laboratory, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Med Sci (Paris)
December 2024
IGMM, Univ Montpellier, CNRS, Montpellier, France.
The memory of cellular identity is crucial for the correct development of an individual and is maintained throughout life by the epigenome. Chromatin marks, such as DNA methylation and histone modifications, ensure the stability of gene expression programmes over time and through cell division. Loss of these marks can lead to severe pathologies, including cancer and developmental syndromes.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Radiation Oncology, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, P. R. China.
Glioblastoma (GBM) remains a daunting oncological challenge because of its aggressive nature and resistance to conventional therapies. Inhibition of the intrinsic STING pathway in GBM hampers the effectiveness of immunotherapies. To overcome this clinical limitation, a Sequential Release HydroLipo System (SRHLS) is developed, in which hydrogels and nanoparticles are combined for controlled drug release.
View Article and Find Full Text PDFSoft Matter
December 2024
Beijing Institute of Technology, Beijing 100021, P. R. China.
Inspired by the complex fractal morphologies and deformations observed in animals and plants, an -dimensional soft structure composed of stretchable electronic bits has been developed. This soft structure, capable of independent and cooperative motion, can be manipulated through the programming of bits using a machine language based on instruction encoding. This method simplifies the process of changing the bit's step temperature to control its binary state.
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