Objective: To shed light on the association of age, smoking, educational status, family history, diabetes and kidney diseases with hypertension.
Methods: The case-control study was conducted at three different medical centres of Rawalpindi, Pakistan, from December 2016 to July 2017. Data from 549 hypertensive cases and 1451 normotensive controls was collected using a detailed questionnaire and through personal interviews by adopting nonprobability consecutive sampling technique. Overall 2000 adult individuals, both males and females excluding pregnant women, were the part of this study. Those with blood pressure ≥140/90mmHg and taking anti-hypertensive treatment were designated as the cases, while the rest were taken as normotensive controls. Blood pressure was measured by a physician. Multivariate logistics regression analysis was used to estimate the association of various different risk factors with hypertension. All the analysis was performed using software R 3.4.2 and SPSS 24.
Results: Of the 2,000 subjects, 549(27.45%) were hypertensive cases and 1451(72.55%) were normotensive controls. Mean age of the cases was 43.32}9.7 years and it was 31.8}10.1 years among the normotensives. Higher age, smoking, lower educational status, presence of kidney diseases, diabetes and family history of hypertension were significantly associated with hypertension (p<0.01 each).
Conclusions: In Pakistani population, age, smoking, illiteracy, kidney diseases, diabetes and family history were found to be associated with hypertension.
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Womens Health (Lond)
January 2025
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Background: Women with previous hypertensive disorders of pregnancy (HDP) have increased risk of cardiovascular disease (CVD). Overweight is a modifiable risk factor for both conditions. Anthropometric indices such as waist circumference, hip circumference, waist-to-hip ratio, estimated total body fat, a body shape index, waist-to-hip-to-height ratio, and index of central obesity improve estimation of cardiovascular death risk in the general population as compared to body mass index (BMI).
View Article and Find Full Text PDFAppl Physiol Nutr Metab
January 2025
University of Saskatchewan, Saskatoon, Saskatchewan, Canada;
We compared stretching, isometrics, and aerobic exercise for effectiveness in decreasing blood pressure post-exercise. Using a randomized crossover design, 5 males and 4 females (21.3y; normotensive) participated in four 30-minute sessions on separate days: static stretching (30s stretches, major muscle groups), isometric exercise, aerobic cycling (75% VO2peak), and control (rest), with blood pressure and heart rate measured before exercise (or rest) and for 60 minutes post-exercise (or rest).
View Article and Find Full Text PDFMetabolomics
January 2025
Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Introduction: Preeclampsia (PE) is a common vascular pregnancy disorder affecting maternal and fetal metabolism with severe immediate and long-term consequences in mothers and infants. During pregnancy, metabolites in the maternal circulation pass through the placenta to the fetus. Meconium, a first stool of the neonate, offers a view to maternal and fetoplacental unit metabolism and could add to knowledge on the effects of PE on the fetus and newborn.
View Article and Find Full Text PDFPurpose: To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing's disease.
Methods: Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.
Expert Rev Hematol
January 2025
Department of Pathology, Nishtar Medical University and Hospital, Multan, Pakistan.
Background: To compare platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) between women with preeclampsia (PE) and normotensive pregnant women, and evaluate their effectiveness as predictors of PE.
Research Design And Methods: This cross-sectional study at Nishtar Hospital, Multan, included 141 women: 74 normotensive and 67 preeclamptic. Data was collected using an automated hematology analyzer and analyzed with SPSS version 26 and ROC curves.
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