Controversies and challenges in HLA-haplotype-matched transplants for leukaemia.

Bone Marrow Transplant

Haematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College, London, UK.

Published: August 2019

AI Article Synopsis

  • This issue discusses the growing use of HLA-haplotype-matched transplants in leukemia patients and the results achieved.
  • The focus is on examining controversies and challenges surrounding the execution and criteria of these transplants rather than the outcomes themselves.
  • Key questions include the best transplant techniques, ideal donor selection, appropriate recipient criteria, comparison with other donor transplants, and strategies for improving outcomes.

Article Abstract

Many typescripts in this issue describe increasing use of HLA-haplotype-matched transplants in persons with leukaemia and report outcomes. Consequently, my goal is not to repeat these data but to focus on controversies and challenges relevant to this topic including: (1) what is the best technique for performing these transplants; (2) who is the best donor; (3) who should receive this type of transplant; (4) how do results compare with transplants from other donors; and (5) how can results be improved.

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Source
http://dx.doi.org/10.1038/s41409-019-0611-4DOI Listing

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