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Straight to the heart: Protecting the patient's heart during chemotherapy.
Cell Stem Cell
December 2024
Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia; The Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC, Australia; Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC, Australia. Electronic address:
How do we protect the heart during chemotherapy with the anthracycline drug class? Tackling this question, Liu et al. combined pluripotent stem cell models, CRISPR genetic screens, and molecular modeling to identify indisulam as a potential cardioprotective drug in this issue of Cell Stem Cell.
View Article and Find Full Text PDFPrevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population.
JAMA Cardiol
November 2024
Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom.
Article Synopsis
- * Conducted with data from the UK Biobank, which included extensive genetic, electrocardiogram, and imaging data from nearly 470,000 participants, the study found that 0.1% carried likely pathogenic TTR variants.
- * Results showed a significant difference in variant prevalence based on ancestry, with a 0.02% prevalence in individuals of European ancestry versus 4.3% in those of African ancestry, highlighting the need for more targeted research and awareness.
Reply to Editorial Comment on "Natural History of Artificial Urinary Sphincter Erosion: Long-term Lower Urinary Tract Outcomes and Incontinence Management".
Urology
November 2024
Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:
Curating an online checklist for Erica L. (Ericaceae): contributing to and supporting global conservation through the World Flora Online.
PhytoKeys
June 2024
University Museum, University of Bergen, Postboks 7800, NO-5020 Bergen, Norway.
To support the work of the Global Conservation Consortium for and update the checklist in the World Flora Online (WFO), we have curated the taxonomic backbone in the WFO by expanding it to include updated nomenclatural information from the International Plant Name Index, missing names present in the World Checklist of Vascular Plants (WCVP), the Botanical Database of Southern Africa (BODATSA), and from the "International register of heather names" database, a data source not readily available online. The result is the most robust database of names to date, including 851 species, 111 subspecies, 244 varieties, and 2787 synonyms, which is a reliable reference for initiatives such as the identification aid, conservation prioritisation, and gap analyses. We disambiguate common orthographic variants within the database and present an overview of these.
View Article and Find Full Text PDFResponse to the letter to the editor regarding "Mobile phone use and brain tumour risk - COSMOS, a prospective cohort study".
Environ Int
July 2024
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Medical Research Council (MRC) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; National Institute for Health Research (NIHR) Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK. Electronic address:
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