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A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). | LitMetric
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A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN).

Dirk Rades Carlos A Narvaez Laura Splettstößer Claudia Dömer Cornelia Setter Christian Idel Julika Ribbat-Idel Sven Perner Tobias Bartscht Denise Olbrich Steven E Schild Jesper Carl

Radiother Oncol

Department of Oncology & Palliative Units, Zealand University Hospital, Naestved, Denmark.

Published: October 2019

Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

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 Source
http://dx.doi.org/10.1016/j.radonc.2019.07.023DOI Listing

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