New diterpenes, namely, trichodermanins F-H, with a fused 6-5-6-6 ring system were isolated from the fungus OUPS-111D-4 separated from a marine sponge . These chemical structures were elucidated by 1D and 2D NMR as well as high-resolution fast atom bombardment mass spectrometry (HRFABMS) spectral analyses. We established their absolute stereostructures by application of the modified Mosher's method or circular dichroism (CD) spectroscopy. In addition, their cytotoxicities were assessed using several cancer cell lines, with and exhibiting modest activities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722853 | PMC |
| http://dx.doi.org/10.3390/md17080480 | DOI Listing |
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