Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior , Ciudad Universitaria, Coyoacán 04510 , Cd. Mx , Mexico.
Published: September 2019
AI Article Synopsis
Article Abstract
Chemical investigation of the aerial parts (except fruits and calixes) of var. led to the isolation of a series of new labdane-type diterpenoids, including the closely related compounds -, the labdane glucosides and , a mixture of the epimeric alcohols and , and one labdanetriol, isolated as its tri--acetyl derivative . In addition, three new withanolides (-) and six known compounds were isolated. The structures of these compounds were elucidated by analysis of their spectroscopic data and chemical transformations, and those of compounds , , and were confirmed by X-ray diffraction analysis of the natural product () and of the corresponding acetyl derivatives and . Fourteen of these compounds were assayed for their in vitro inhibitory activity against yeast α-glucosidase and acetylcholinesterase enzymes. The results were negative in both cases, except for compound that marginally inhibited the activity of acetylcholinesterase with an IC value of 64.4 μM.
Introduction: The roots and rhizomes of Curcuma longa L. serve as distinct traditional Chinese medicines with varying therapeutic effects, likely attributed to differences in the accumulation and distribution of metabolites in these parts.
Objective: The study aims to investigate the differences and spatial distribution patterns of metabolites in C.
Background: Women who had preeclampsia (a history of preeclampsia) have a >4-fold risk of developing cardiovascular disease compared with women who had an uncomplicated pregnancy (history of healthy pregnancy). Despite the remission of clinical symptoms after pregnancy, vascular endothelial dysfunction persists postpartum, mediated in part by exaggerated Ang II (angiotensin II)-mediated constriction. However, the role of vasodilatory ATRs (Ang II type 2 receptors) in this dysfunction is unknown.
Drug checking services (DCS) are entities that allow recreational drug users to have street drug samples analyzed. Diverse analytical methods are applied for DCS, ranging from test strips to mass spectrometry (MS). This work evaluates the performance and utility of common methodologies used for DCS operating with off-site drug testing, while additionally assessing the potential of gas chromatography coupled to vapor phase infrared spectroscopy (GC-IR).
is an edible and medicinal mushroom. Previously, we found hericenones C-H from the fruiting bodies and erinacines A-I from the mycelia of the fungus. These compounds stimulated nerve growth factor (NGF) synthesis both and ; some have been suggested to be effective in the prevention and treatment of dementia.
Introduction: Cohen syndrome (CS) is an early-onset pediatric neurodevelopmental disorder characterized by postnatal microcephaly and intellectual disability. An accurate diagnosis for individuals with CS is crucial, particularly for their caretakers and future prospects. CS is predominantly caused by rare homozygous or compound heterozygous pathogenic variants in the vacuolar protein sorting-associated 13B () gene, which disrupt protein translation and lead to a loss of function (LoF) of the encoded VPS13B protein.
