AI Article Synopsis
- The study investigated the impact of zoledronic acid treatment on daily living activities, cognitive functions, depression, muscle strength, and overall performance.
- A total of 115 patients were analyzed, showing significant increases in bone mineral density after treatment but a decline in cognitive functioning and gait speed.
- Ultimately, the findings suggested that while zoledronic acid improves bone density, it may negatively affect cognitive aspects and muscle performance without significantly impacting daily living activities or levels of depression.
Article Abstract
Background: We aimed to investigate the effects of zoledronic acid treatment on daily living activities, cognitive functions, depression, muscle strength, and performance.
Methods: The study was conducted retrospectively. Bone mineral densitometry (BMD) values, Katz activities of daily living (ADL), Lawton-Brody instrumental activities of daily living (IADL), mini mental state examination (MMSE), geriatric depression scale (GDS), mini nutritional assessment (MNA), grip strength, and gait speed scores before and 6 months after zoledronic acid administration were compared.
Results: A total of 115 patients were included in the study. There was a significant increase in lumbar total (p < .001), femoral neck (p = .002), and femur total (p = .001) BMD values after zoledronic acid treatment. Significant decrease was found in MMSE (p = .016) and gait speed scores (p = .008) after zoledronic acid treatment, but no significant difference was found in terms of Katz ADL, Lawton-Brody IADL, MNA, GDS, and grip strength (p > .05).
Conclusion: Our study indicated that zoledronic acid did not affect daily living activities, depression, and muscle strength. Although we have concluded that cognitive and muscle performance may be adversely affected by zoledronic acid treatment.
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| http://dx.doi.org/10.1007/s11845-019-02086-5 | DOI Listing |
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