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| http://dx.doi.org/10.1007/s10278-019-00263-7 | DOI Listing |
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Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.
JMIR Aging
June 2024
see Acknowledgements, San Francisco, CA, United States.
Background: Frontotemporal lobar degeneration (FTLD) is a leading cause of dementia in individuals aged <65 years. Several challenges to conducting in-person evaluations in FTLD illustrate an urgent need to develop remote, accessible, and low-burden assessment techniques. Studies of unobtrusive monitoring of at-home computer use in older adults with mild cognitive impairment show that declining function is reflected in reduced computer use; however, associations with smartphone use are unknown.
View Article and Find Full Text PDFPathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort.
Alzheimers Dement
November 2023
Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.
Article Synopsis
- The LEADS study focuses on understanding the genetic causes of early-onset Alzheimer's Disease (EOAD), specifically in individuals aged 40-64, by screening for known pathogenic variants.
- *Whole exome sequencing of 299 participants found pathogenic variants in 1.35% of EOAD cases and 6.58% of early-onset non-Alzheimer's disease cases, but no gene showed a significant enrichment for rare functional variants.
- *The findings suggest that LEADS may include new genetic variants related to early-onset cognitive impairment, making it an important resource for ongoing Alzheimer's research.*
Smartphone apps for point-of-care information summaries: systematic assessment of the quality and content.
BMJ Evid Based Med
October 2023
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Background: Clinicians need easy access to evidence-based information to inform their clinical practice. Point-of-care information summaries are increasingly available in the form of smartphone apps. However, the quality of information from the apps is questionable as there is currently no regulation on the content of the medical apps.
View Article and Find Full Text PDFA Precision Medicine Tool for Patients With Multiple Sclerosis (the Open MS BioScreen): Human-Centered Design and Development.
J Med Internet Res
July 2020
Department of Neurology, UCSF Weill Institute for Neurosciences, San Francisco, CA, United States.
Background: Patients with multiple sclerosis (MS) face several challenges in accessing clinical tools to help them monitor, understand, and make meaningful decisions about their disease course. The University of California San Francisco MS BioScreen is a web-based precision medicine tool initially designed to be clinician facing. We aimed to design a second, openly available tool, Open MS BioScreen, that would be accessible, understandable, and actionable by people with MS.
View Article and Find Full Text PDFAssociation of Acquired and Heritable Factors With Intergenerational Differences in Age at Symptomatic Onset of Alzheimer Disease Between Offspring and Parents With Dementia.
JAMA Netw Open
October 2019
Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine in St Louis, St Louis, Missouri.
Importance: Acquired and heritable traits are associated with dementia risk; however, how these traits are associated with age at symptomatic onset (AAO) of Alzheimer disease (AD) is unknown. Identifying the associations of acquired and heritable factors with variability in intergenerational AAO of AD could facilitate diagnosis, assessment, and counseling of the offspring of parents with AD.
Objective: To quantify the associations of acquired and heritable factors with intergenerational differences in AAO of AD.
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