Children with traumatic brain injury (TBI) are reported to have persistent deficits in executive functioning and subtle motor functions This study examined the relationship between subtle motor signs and executive functioning in children with TBI Eighteen children aged 13-18 years with mild to severe TBI at least one year before study participation and 16 age-matched typically-developing controls were examined using the Revised Physical and Neurological Examination of Subtle Signs (PANESS), a simplified Go/No-go task, portions of the Delis-Kaplan Executive Function System Verbal Fluency and Trail Making tests, and a Wechsler Coding test There were significant associations between PANESS scores and executive functioning measures in children with TBI but not in controls. Conclusion: Results suggest that assessment of subtle motor signs may provide broader information regarding functioning after pediatric TBI.
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http://dx.doi.org/10.1080/17518423.2019.1655676 | DOI Listing |
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View Article and Find Full Text PDFThe NSD-ISS Working Group developed a data-driven approach to: 1) determine a biologic definition for disease; 2) establish a framework for a disease staging platform. NSD is defined by the presence of pathologic n-asyn (S) assessed by a validated in vivo biomarker and ultimate presence of dopaminergic neuronal dysfunction (D). This biologic definition is independent of the presence of clinical features, or if present, of the specific clinical syndrome.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: TDP-43 (TAR DNA-binding protein 43) is one of the most frequently observed co-pathologies in Alzheimer's disease (AD). Recognizing the diversity of pathological features in individuals with AD, including the presence of TDP-43, may lead to more personalized and effective treatment approaches. We investigate ante-mortem cortical microstructural changes in MRI with subsequent autopsy confirmation of Alzheimer's disease neuropathological changes (ADNC) with and without TDP-43 comorbidity.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
Background: Finding low-cost, accessible methods to detect people with early-stage Alzheimer's disease is a research priority for neuroprotective drug development. Subtle motor impairment of gait occurs years before episodic memory decline but there has been little investigation of whether self-administered hand motor tests can detect this pre-symptomatic period. This study evaluated how home-based unsupervised keyboard tapping tests from the TAS Test protocol predict episodic memory performance in a sample of older adults without overt cognitive impairment, as a potential indicative measure of early Alzheimer's disease.
View Article and Find Full Text PDFBackground: Digital cognitive tools offer novel ways to detect early cognitive changes associated with preclinical Alzheimer's disease (AD). A digital version of the maze test (dMaze) was recently developed using a digital pen (12 ms temporal precision) to uniquely capture the process of test completion, reflecting the thinking effort, potentially more sensitive to early cognitive deficits in preclinical AD. The sensitivity of these novel digital maze test variables-Wall Penetration Count and Speed Standard Deviation (Speed SD)-to detect early amyloid-β burden was evaluated, hypothesizing that greater amyloid accumulation would be associated with greater variability of speed, and more wall penetration errors while completing the task, reflecting a greater thinking effort.
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