AI Article Synopsis
- Wilson disease (WD) is a rare genetic disorder that disrupts copper metabolism, leading to a variety of symptoms, including neurological and psychiatric issues.
- Approximately 30% of patients first show signs of the disease through neuropsychiatric symptoms, which can delay diagnosis and treatment.
- Early detection of WD is crucial as it can prevent long-term neurological damage, particularly for those initially presenting with psychiatric symptoms.
Article Abstract
Wilson disease (WD) is an uncommon recessive genetic disorder affecting copper metabolism. Cardiac, neurological, hepatic and renal manifestations are well defined, nevertheless approximately 30% of patients debut with neuropsychiatric symptoms. These psychiatric alterations resulting from the accumulation of this heavy metal in the basal ganglia are some how less specific. We present a short review of psychiatric symptoms of WD and describe a case of a 37-year-old woman diagnosed with WD who presented neuropsychiatric symptoms and had a consequent delay in diagnosis and causal treatment. Patients who develop WD starting with a predominance of neuropsychiatric symptoms tend to manifest hepatic symptoms later, therefore have a longer delay of diagnosis and a poorer outcome than patients with hepatic symptoms. An early diagnosis of WD can avoid irreversible neurological damage.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677933 | PMC |
| http://dx.doi.org/10.1136/gpsych-2019-100066 | DOI Listing |
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