AI Article Synopsis
- The mtr locus in Neisseria gonorrhoeae contributes to low-level antibiotic resistance and can be suppressed by env mutations that enhance envelope permeability.
- A new locus, mom, is identified near penB and nmp, both of which are associated with antibiotic resistance.
- Mutations in mom can restore the Mtr phenotype, allowing certain gonococci to revert to resistance against multiple antibiotics, despite appearing sensitive initially.
Article Abstract
The chromosomal locus mtr, which encodes low-level resistance to multiple antibacterial agents in Neisseria gonorrhoeae, is subject to phenotypic suppression by env mutations that increase the permeability of the envelope. We have identified a new locus, mom (for modifier of Mtr), which is located on the chromosome very close to penB and nmp, loci known to be linked to each other and to spc. Phenotypic suppression of Mtr was recognized by reductions of resistance to benzylpenicillin and also to oxacillin and the hydrophobic agents novobiocin and erythromycin. The resistance to each of these antibiotics returned to the Mtr levels in mom+ transformants isolated by selection for increased resistance to either novobiocin or erythromycin; the accompanying change of the outer membrane protein I seroreactions confirmed the proximity of nmp and mom. Thus, some mutant gonococci display wild-type antibiotic susceptibilities but can express multiple resistance following a mom+ mutation that releases the suppressed Mtr phenotype.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172327 | PMC |
| http://dx.doi.org/10.1128/AAC.32.7.971 | DOI Listing |
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