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Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. | LitMetric

AI Article Synopsis

  • Researchers explored how cells transition into a naive pluripotent state, discovering that this process can happen through different pathways.
  • One pathway involves a mesodermal state, while another resembles the early inner cell mass, leading to a greater ability to develop into various cell types.
  • Both pathways eventually converge into the same naive pluripotent state, emphasizing the flexibility of these identity transitions and highlighting the essential role of the transcription factor Oct4 in regulating this process.

Article Abstract

Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct routes. Starting from post-implantation epiblast stem cells (EpiSCs), one route advances through a mesodermal state prior to naive pluripotency induction, whereas another transiently resembles the early inner cell mass and correspondingly gains greater developmental potency. These routes utilize distinct signaling networks and transcription factors but subsequently converge on the same naive endpoint, showing surprising flexibility in mechanisms underlying identity transitions and suggesting that naive pluripotency is a multidimensional attractor state. These route differences are reconciled by precise expression of Oct4 as a unifying, essential, and sufficient feature. We propose that fine-tuned regulation of this "transition factor" underpins multidimensional access to naive pluripotency, offering a conceptual framework for understanding cell identity transitions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731995PMC
http://dx.doi.org/10.1016/j.stem.2019.07.009DOI Listing

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