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LAG Time in the Era of Immunotherapy-New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene-3.
Immunol Rev
March 2025
Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USA.
The immune checkpoint receptor lymphocyte activation gene-3 (LAG3) inhibits T-cell activation and was recently validated as a target for cancer immunotherapy. Despite its emergence as a therapeutic target, a lack of molecular-level insight has obscured our understanding of the LAG3 immunosuppression mechanism. This review highlights a series of breakthroughs that have illuminated fundamental aspects of LAG3 molecular biology.
View Article and Find Full Text PDFThe aging human larynx, presbyphonia, and voice quality: The evolutionary and social effects on listeners.
Anat Rec (Hoboken)
January 2025
Department of Otolaryngology-Head & Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
The human voice is a major signal transmission modality for our species. Accordingly, perception of its quality serves as an intraspecific window into the status of an individual's health, robusticity, and even stature in the group. Diminished quality-as may occur in aging or certain diseases-is a major feature in the lessening of an individual's communication modality.
View Article and Find Full Text PDFBackground: Restless legs syndrome (RLS) is a common sensory-motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed. The dysfunction of the A11 nucleus, which modulates dopaminergic transmission to the spinal cord, is thought to play a role in RLS pathophysiology.
View Article and Find Full Text PDFColorectal adenosquamous carcinoma: clinicopathologic analysis of two large cohorts and literature review confirm poor prognosis and reveal prognostic aspects.
Histopathology
January 2025
Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
Aims: We compiled two cohorts of colorectal adenosquamous carcinoma (ASC) to describe its histologic and molecular aspects using modern parameters to compare them with literature reports using meta-analysis of cohorts and individual case series.
Methods And Results: We identified 53 colorectal ASC from 19 North American academic medical centres, in addition to national database reports on 94 Dutch cases. We analysed available clinical, histologic, and immunohistochemical features and patient outcome.
Pharmacovigilance Indicators in Health Services: A Systematic Review. Are There Still Relevant Gaps?
J Patient Saf
February 2025
Faculty of Pharmacy, Federal University of Rio de Janeiro.
Objective: The aim of this study was to identify potentially applicable pharmacovigilance (PV) indicators for health services available in the literature.
Methods: We searched MEDLINE, EMBASE, LILACS, IBECS, CUMED, SciELO, and Google Scholar bibliographic between January 1, 2004 and January 23, 2023, and 25 websites from different organizations for studies describing specific PV indicators in health services. The methodological quality of the included studies was assessed using the Appraisal of Indicators through the Research and Evaluation (AIRE) tool.
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