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Investigating Parkinson's disease risk across farming activities using data mining and large-scale administrative health data.
NPJ Parkinsons Dis
January 2025
Univ. Grenoble Alpes, AGEIS, 38000, Grenoble, France.
The risk of Parkinson's disease (PD) associated with farming has received considerable attention, in particular for pesticide exposure. However, data on PD risk associated with specific farming activities is lacking. We aimed to explore whether specific farming activities exhibited a higher risk of PD than others among the entire French farm manager (FM) population.
View Article and Find Full Text PDFEnhanced immunogenicity of a BoHV-1 gG-/tk- vaccine.
Vaccine
January 2025
National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China; Key Laboratory of development of veterinary diagnostic products, Ministry of Agriculture and Rural Affair, Wuhan 430070, China. Electronic address:
Bovine herpesvirus type 1 (BoHV-1) is a widespread respiratory infection that significantly impacts cattle health worldwide. To address this issue in China, we previously developed a novel double gene-deleted vaccine targeting gG and tk. In this study, we further evaluated the efficacy of this vaccine by challenging vaccinated cattle with a prevalent wild-type BoHV-1 strain and comparing its effectiveness against a commercially available inactivated BoHV-1 vaccine.
View Article and Find Full Text PDFAlthough the highlands of East Africa lack the geo-ecological landmarks of Rift Valley fever (RVF) disease hotspots to participate in cyclic RVF epidemics, they have recently reported growing numbers of small RVF clusters. Here, we investigated whether RVF cycling occurred among livestock and humans in the central highlands of Kenya during inter-epidemic periods. A 2-year prospective hospital-based study among febrile patients (March 2022-February 2024) in Murang'a County of Kenya was followed by a cross-sectional human-animal survey.
View Article and Find Full Text PDFThousands of Years of Pastoralism Don't Count: Coprophagous Beetles Prefer Exotic Alpaca Dung to That of Cattle.
Insects
November 2024
Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Via Accademia Albertina 13, 10123 Torino, Italy.
Dung beetles mostly feed on mammal dung. Throughout the European Alps, the dung produced by local domestic ungulates attracts many species of dung beetles, giving rise to rich and diversified communities that play an important role in the Alpine agricultural ecosystem. There is, therefore, understandable concern about the introduction of exotic livestock, such as alpacas ( (Linnaeus, 1758)), into the region.
View Article and Find Full Text PDF6-Aza-2-Thiothymine as an Alternative Matrix for Spatial Proteomics with MALDI-MSI.
Int J Mol Sci
December 2024
Proteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Matrix Assisted Laser Desorption/Ionisation-Mass Spectrometry Imaging (MALDI-MSI) is a well-established spatial omic technique which enables the untargeted mapping of various classes of biomolecules, including tryptic peptides, directly on tissue. This method relies on the use of matrices for the ionisation and volatilisation of analytes, and α-Cyano-4-hydroxycinnamic acid (CHCA) represents the most widespread matrix for tryptic peptides analysis. However, CHCA also presents certain limitations that foster the quest for novel matrix compounds.
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